Modern working environments bring about potential for personal growth but also health-, performance-, and motivation-related risks. From the review of former literature, job resources as well as personal resources appear to play a key role for the adaptation to constant changes of working environments today. The present study replicated and extended an integrated model of job design, incorporating psychological demands, job resources, and personal resources. N = 172 German and Austrian workers from different professions filled out an online questionnaire to participate in the present study. The interplay of psychological demands, job resources, and personal resources was investigated. Findings revealed significant main effects for psychological demands, job resources, and personal resources on personal and organizational outcomes. Additionally, the data revealed moderation effects for self-leadership and autonomy. However, some findings were contrary to expectations, highlighting the importance of further investigation of other work-related factors such as competence and individual differences, for instance.