Introduction: Oxidative stress is an imbalance between reactive oxygen species (ROS) and antioxidants. Especially in extreme environmental conditions like cold temperatures, physical exercise evokes oxidative stress, which is connected with higher amounts of ROS. The higher levels of ROS may contribute to restricted exercise performance and the inhalation of cold air may lead to bronchoconstriction. The aim of this study was to evaluate if antioxidant supplementation (Sanopal) would lead to a reduction in bronchoconstriction and a rise in exercise performance when exercising in the cold (-15C).
Material and Methods: The study was carried out as a double blind and randomised placebo-crossover-study.The study design consisted of a graded exercise test to exhaustion on a treadmill and two submaximal runs with 80% of the individual VO2max in an environmental chamber in the cold (-15C). 11 women participated in the study and received a short-term supplementation with Sanopal or Placebo before the submaximal running in the cold. Time until exhaustion, heart rate (HR), rating of perceived exertion (RPE) and respiratory function (FVC, FEV1) were measured. The Statistical analysis was performed using SPSS version 21.0. A p value < 0.05 was considered significant.
Results: There was no significant change in time until exhaustion (p=.475), mean heart rate (0.088) and RPE (0.858) through the intake of Sanopal compared to Placebo. The point in time (before and after the test in the cold) had a significant effect on the change in FVC with placebo and supplement (p=.002) and in FEV1 (p=.003). Sanopal had no effect on the change in FVC (p=.819) and FEV1 (p=.923) before and after the cold compared with placebo.
Discussion: Short-term supplementation with -ketoglutaric acid and 5-hydroxymethylfurfural showed no increase in exercise performance and changes in mean heart rate and RPE in submaximal running in the cold. This is in accordance with other publications. The significant change in respiratory function (FVC, FEV1) before and after running in cold temperatures was shown in other studies previously. Further studies are necessary to see if long term supplementation would have an effect on exercise performance in the cold in healthy females.