In recent years, corporates that embrace an open innovation strategy increasingly turn to startups as an external source of innovation. Startups offer promising new ideas whereas corporates are generally capable of providing a pool of resources and organizational know-how. Startup programs offer a potent approach to bridge both parties to embrace each others potential and to establish a mutually beneficial collaboration. However, indifferent to the type of startup program, differences between corporates and startups challenge collaborations and consequently their potential of an ongoing post-program partnership. Therefore, corporate-startup collaborations require a design framework that is capable of adding value to both startups and corporates during the program as well as to enable long-term partnerships. Based on the data, generated through interviews with corporate managers, mentors, and startups (n=20), this study suggests design principles for how organizations can systematically foster innovation through collaborating with startups beyond the boundaries of a specific startup program. The results indicate that in order to successfully nurture and later integrate startup-driven innovations, corporates need to consider the design dimensions, purpose, program, process, partnership, people, and place as well as their interrelations and impact on one another. This framework enables corporations to foster corporate startup-driven innovation and assists in integrating corporate-startup collaborations in a corporates overall innovation strategy.